Icahn School of Medicine at Mount Sinai Levy Library

Online Sources for Information About Animal Testing Alternatives

The sites listed below were selected because they offer current, authoritative information and resources for improved animal care and use in research, testing, and teaching. Most include conference reports and newly issued protocols. Many offer newsletters or other regular information updates to assist investigators and Institutional Animal Care Use Committees to stay up to date with developments in animal testing and alternatives.

Animal Welfare Information Center (AWIC)
The Animal Welfare Information Center (AWIC), a service of the United States Department of Agriculture's National Agriculture Library, is mandated by the Animal Welfare Act (AWA) to provide information for improved animal care and use in research, testing, teaching and exhibition. The Animal Welfare Act specifically mentions AWIC as a resource for primary investigators searching for the availability of alternatives to animal testing. The Alternatives site in AWIC provides information on methods and sources available to reduce, refine or replace animals used in teaching, testing and research.

AltWeb, the Alternatives to Animal Testing Web Site, is an international online clearinghouse for alternatives news, information, and resources. Alt Web is managed by The Johns Hopkins Center for Alternatives to Animal Testing (CAAT). AltWeb assists scientists and others conducting searches for alternative methods and to serve as a central reference point for alternatives information, publications, databases and other resources. Among other services, it offers a tutorial on searching for alternatives to animal testing. Recent news items are available on the AltWeb home page and archived on the site.

The European Centre for the Validation of Alternative Methods (EVCAM)
Founded on a directive of the European Commission, EVCAM promotes the scientific and regulatory acceptance of non-animal tests through research, test development and validation. It focuses on toxicity studies of chemical products, particularly medicines, vaccines and cosmetics. It validates alternative methods, provides training and publishes animal testing alternatives protocols.

Fund for the Replacement of Animals in Experiments (FRAME)
FRAME, a charitable organization based in the United Kingdom, conducts research on alternatives, offers a guide to searching for alternatives, and provides information, education and lobbying to replace, reduce or refine the use of animals in research. In addition to publishing a peer reviewed journal, ALTA, FRAME publishes a newsletter, FRAME News.

IACUC.ORG, produced by the American Association for Laboratory Animal Science (AALAS), is an information resource for members and staff of Institutional Animal Care and Use Committees (IACUC). It provides a directory of links to websites on a range of topics of interest to IACUCs, including a section on alternatives. It also sponsors IACUC-FORUM, a closed listserv where IACUC members from research institutions in the United States may privately discuss issues relating to laboratory animal research.

The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM)
The National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM)
ICCVAM, established by the National Institute of Environmental Health Sciences (NIEHS) is composed of representatives from 15 Federal regulatory and research agencies. The National Toxicology Program (NTP) at the National Institute of Environmental Health Sciences (NIEHS) created the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM or "the Center") to administer ICCVAM and provides operational and scientific support for ICCVAM and ICCVAM-related activities. NICEATM and ICCVAM work collaboratively to evaluate new and improved test methods applicable to the needs of U.S. Federal agencies. Meeting reports, information and updates are available.

National Centre for the Replacement, Refinement and Reduction of Animals in Research ( NC3Rs)
NC3Rs is a public-private partnership in the United Kingdom for the promotion, development and implementation of the 3 Rs in animal research and testing; it provides a forum for industry, academia, regulatory agencies and the animal protection community to work together. The Centre funds 3 Rs research, organizes workshops and symposia to disseminate and advance the 3 Rs, and develops 3 Rs information resources and guidelines. Their Information Portal offers a comprehensive directory to online resources in all areas of laboratory animal welfare. News updates and articles are published on the site, and free registration is available for the Newsletter.

NIH Animals in Research Web Site
This site from the NIH's Office of Extramural Research provides news, policies, education, training and information on the use of animals in research. Information is provided for researchers and institutions as well as the general public.

Recognizing Pain in Animals
From the Institute for Laboratory Animal Research of the National Academies, this is a guide to recognizing, minimizing and alleviating pain in laboratory animals without compromising the methodological integrity of research projects.

Scientists Center for Animal Welfare (SCAW)
SCAW is a nonprofit educational association of individuals and institutions whose mission is to promote best practices for the management of animals involved in reseach, labororatory, agricultural and other settings. It is affiliated with the American Association for the Advancement of Science, Altweb, and the American Association for Laboratory Animal Science, among others. SCAW offers IACUC Talk, an online forum that is open to everyone, but that is designed to allow IACUC members to discuss protocols and research into animal well being, as well as other topics.

The University of California Center for Animal Alternatives
The UC Center for Animal Alternatives is a comprehensive portal offering information about animal alternatives and methods for improving animal care. The site maintains a comprehensive directory of organizations and web resources. It also provides tutorials and one-click search templates for a wide range of topics regarding alternatives to animal use in both research and education.

The Mount Sinai IACUC provides the forms needed to document searches for alternatives to animal testing. Its Resources page links to the Guide for the Care and Use of Laboratory Animals, the full text of the Animal Welfare Act, and the Public Health Service Policy on Humane Care and Use of Laboratory Animals.

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Last updated June 2009